Overview of Cancer in Asia

M Smith
Scientific Communications (UK), London, UK

 

Introduction

Causes of death have dramatically changed in Asia in conjunction with economic growth and increasing life expectancy in the area. In countries where communicable diseases once ranked as the leading cause of death, cancer and cardiovascular disease are now becoming the main causes of mortality and morbidity.

Cancer is a significant health problem in Asia, being the leading cause of mortality in Taiwan, Thailand, Singapore, Korea, Hong Kong, and Japan. The disease is becoming an increasingly important health concern in countries such as Malaysia and The Philippines as the impact of communicable diseases decreases with the widespread supply of clean water and sanitation facilities. Cancer is the third and fourth leading cause of death in The Philippines and Malaysia, respectively. However, in poorer countries such as Vietnam, where malnutrition and infectious diseases are still major health problems, cancer ranks in a relatively modest position of priority. This paper describes the situation throughout Asia with reference to the main sites of disease and prevention and control strategies.

 

Bangladesh

The top sites for malignancies among men in Bangladesh are the bronchus, oropharynx, oesophagus, oral cavity, stomach, hypopharynx, carcinoma of unknown primary, lymphoma, and liver. The main sites for females are the cervix, breast, oesophagus, bronchus, oropharynx, ovary, larynx, stomach, oral cavity, and hypopharynx. Irrespective of gender, the main malignant sites are the bronchus, oesophagus, oropharynx, cervix, and larynx. Overall, head and neck cancers comprise more than one-third of all malignancies in the country.

Most patients with cancer present at an advanced stage of the disease due to illiteracy, lack of awareness, religious prejudice, wide availability of non-traditional treatment, and inadequate diagnostic facilities. The government infrastructure for health care delivery in Bangladesh is generally good, although the provision for clinical oncology is inadequate, with insufficient facilities for creating awareness, screening, diagnosis, and treatment. Early detection and prevention of cancer therefore require serious thought and attention.

 

China

There is no doubt that the incidence of cancer in China is increasing. In the early 1990s (1990 to 1992), the cancer mortality rate was 108.26 per 100,000 population, accounting for 17.94% of all deaths. This was an increase of 11.56% from an earlier survey performed in the 1970s (1973 to 1975). Cancer is now the second leading cause of death in the country after respiratory diseases. Approximately 1.3 million people are expected to die of cancer each year.

The main cancer sites are stomach, liver, lung, and oesophagus (Table 1). These 4 cancers account for 74% of all cancer deaths in the country. However, while the mortality rates for stomach and liver cancers have remained stable, the mortality rate for lung cancer has more than doubled since the 1970s. Meanwhile, mortality from cervical, nasopharyngeal, and oesophageal cancers has decreased by 69.00%, 34.62%, and 21.32%, respectively.

Controversy remains about the change in rates for oesophageal cancer, since the classification for oesophageal cancer changed between the 1970s and the 1990s. Although the rate has decreased, it remains at a high level in certain high-risk areas. In addition, this cancer has a tendency to be diagnosed at a late stage so the 5-year survival remains low (ranging from 20% to 30%).

Table 1. Main causes of cancer deaths in China.

Cancer site
Annual death rate

Stomach
Liver
Lung
Oesophagus

302,000
244,000
210,000
209,000

 

Hong Kong

Chronic degenerative diseases now constitute the major causes of death in Hong Kong, with the top 3 morbidities of malignant neoplasms, heart disease, and pneumonia representing 32.7%, 15.5%, and 11.3% of all deaths in 1998, respectively. Cancer is the leading cause of death in Hong Kong, being responsible for 1 in every 3 deaths, although the age-standardised rates of death from cancer have gradually declined during the past 20 years. The leading causes of cancer deaths include lung, liver, colon, stomach, nasopharynx, and breast cancers (Table 2). However, this differs between men and women, with women having a lower incidence of lung, liver, and nasopharyngeal cancers than men (Table 2).

Table 2. Main sites of cancer in men and women in Hong Kong.

All sites
Men
Women

Lung
Liver
Colon
Stomach Nasopharynx
Rectum
Female breast
Oesophagus
Pancreas
Leukaemia

Lung
Liver
Colon
Nasopharynx
Rectum
Stomach
Bladder
Oesophagus
Prostate
Non-Hodgkin's lymphoma

Breast
Lung
Colon
Cervix
Rectum
Liver
Stomach
Nasopharynx
Ovary and uterine adnexa
Thyroid

 

India

India has a population of approximately 1 billion, of whom 3 million will have cancer at any one time, with an annual incidence of approximately 1 million new patients. While cancer is not a common disease in India, an increasing elderly population ensures that the number of people with cancer will increase in the future.

The cancers most frequently seen in India are lifestyle dependent, associated with tobacco use, low socioeconomic status, multiple pregnancies, early age at marriage, and poor sexual hygiene. For example, males tend to have mainly tobacco-related cancers of the oral cavity, pharynx, larynx, oesophagus, and lung, while females have a high incidence of cervical cancer. These factors tend to be related to the population living in rural surroundings (70% of the population live in rural areas). In addition, low socioeconomic status and low literacy rates ensure that most patients are diagnosed at an advanced stage of the disease making it difficult to achieve cure.

It is difficult to obtain accurate cancer statistics in a large country such as India where only 6 cancer registries function for a population of 1 billion. However, the population- based cancer registry in Mumbai (Bombay) has provided the age-adjusted incidence rates of the 10 leading cancers for men and women (Table 3).

The strategy for cancer control in India should focus on health education for the rural population and the creation of an infrastructure for cancer management. Education is a priority to ensure that the population is aware of prudent lifestyle changes for cancer prevention, symptomatology of early cancer for prompt diagnosis, availability of screening programmes for high-risk populations, and the correlation between early diagnosis and long-term disease-free survival.

While increasing longevity will add to the cancer burden in the future, increasing public awareness and improved technology for early diagnosis will add to the number of people who will be diagnosed with the disease. Although many cancers are preventable through lifestyle changes, the impact of this knowledge in reducing the incidence of cancer will take time. However, cancer mortality rates are steadily declining in countries where appropriate strategies have been implemented.

Table 3. Age-standardised incidence rates* for 10 leading cancer sites in India.

Men
Women
Site
Rate per 100,000
Site
Rate per 100,000
Lung
Oesophagus
Prostate
Larynx
Stomach
Tongue
Lymphomas
Hypopharynx
Liver
Leukaemia

10.7
7.3
6.8
6.2
5.5
5.5
4.8
4.5
4.4
4.3

Breast
Cervix
Ovary
Oesophagus
Lung
Leukaemia
Stomach
Uterus
Lymphoma
Colon

28.1
17.1
8.2
6.2
4.5
3.6
3.5
3.4
3.4
2.7

* Adjusted to the world population, aged between 0 and 74 years, as suggested by the World Health Organization.

 

Indonesia

Indonesia is the fifth most populated country in the world after China, India, the Russian Federation, and the USA, with a population of more than 200 million people. While there is an Indonesian cancer society and various research facilities, there are no population-based registries in Indonesia. However, data collected from hospitals in several regions of the country show that the incidence of cancer has increased by up to 8% per year during the past decade.

The 5 main sites for cancer in Indonesia are cervix, breast, lymph node, skin, and nasopharynx. Most patients with cancer are women (65.4%) and the most common female cancer sites are cervix, breast, and ovary (Table 4). An observation period of 4 years (1988 to 1991) shows an increasing rate for each cancer site each year.

Facilities for cancer care have improved in Indonesia. Efforts to control cancer have been undertaken by the government and various other groups. and mainly include prevention, early detection, and treatment. However, rehabilitation, cancer registration, and research are still in their infancy. Activities for primary prevention currently focus on tobacco use, breast self-examination, and screening for cancer of the cervix.

A well-planned cancer control programme aimed at improving cure rates and improved quality of life for patients with cancer is desirable. To achieve these goals, prevention strategies, early detection, diagnosis and treatment, rehabilitation, cancer registration, and research are needed.

Table 4. Ten leading cancer sites in Indonesia according to pathology (1991).

Men
Women
Site
Percent
Site
Percent
Skin
Nasopharynx
Lymph node
Unknown primary
Rectum
Prostate
Soft tissue
Colon
Lung
Bladder

11.59
11.27
10.40
7.50
7.07
4.85
4.19
4.17
3.99
3.97

Cervix
Breast
Ovary
Skin
Thyroid
Unknown primary
Lymph node
Rectum
Nasopharynx
Uterus

28.66
17.77
7.77
5.89
4.61
3.73
3.40
3.20
3.03
3.00

 

Korea

Cancer is one of the most common diseases in Korea, with 50,000 deaths and 80,000 new cases annually. Cancer accounts for 8.3% of all hospital admissions, represented by 9.5% for men and 7.9% for women. According to the Seoul cancer registry data for 1992 to 1995, the crude annual incidence rates for men and women was 184.4 per 100,000 and 158.4 per 100,000, respectively, while the age standardised rate (ASR) for the world population was 290.8 per 100,000 for men and 173.4 per 100,000 for women.

The main cancer site for men and women is the stomach (Table 5). For men, the 4 leading cancer sites of stomach, liver, lung, and colorectum account for two-thirds of all new male cancers. Among women, approximately 60% of all new cancers are accounted for by those of the stomach, cervix, breast, colorectum, and liver. Interestingly, while the leading cancer sites remain relatively similar for men regardless of age, there are differences between older and younger women, notably that middle-aged women (35 to 64 years) are more likely to develop breast cancer than older women, while older women have more lung cancer (Table 6).

Table 5 . Five leading cancer sites in Korea by gender

Men
Women
Site
Percent
Site
Percent
Stomach
Liver
Lung
Colorectum
Bladder

24.7
18.5
15.3
8.5
3.2

Stomach
Cervix
Breast
Colorectum
Liver

17.3
13.5
12.3
9.0
7.2


Table 6 . Five leading cancer sites in Korea by age.

35-64 years
64 years
Site
Percent
Site
Percent
Men
Stomach
Liver
Lung
Colorectum
Bladder
26.1
23.2
13.1
8.6
3.0
Stomach
Lung
Liver
Colorectum
Bladder
24.1
22.1
11.8
8.8
4.1
Women
Cervix
Breast
Stomach
Colorectum
Liver

17.3
17.0
15.5
8.6
7.4

Stomach
Lung
Colorectum
Liver
Cervix

22.0
12.3
11.7
9.0
7.2

 

Of note, is that some parts of Asia, including Korea, have the highest incidence of gastric cancer in the world. A comparison of age incidence curves found that the ASR of gastric cancer for men in Seoul was 10-fold that of men in Los Angeles, USA (71.1 per 100,000 population vs 7.6 per 100,000 population).

Cancer is the leading cause of death in Korea, accounting for 24.1% of all deaths for men and 17.7% for women. There is a marked increase in death rates for people older than 65 years (73% to 75% increase). Gastric cancer mortality has gradually decreased during the past decade, particularly for middle-aged people, while lung cancer mortality is increasing for all age groups. Interestingly, female breast cancer mortality has also increased during the past 10 years.

Early detection or mass screening programmes are available for a fee for specific cancer sites such as stomach, liver, colorectum, breast, and cervix. However, the uptake is less than 10% of the target population and public education is not active. Consequently the early detection rate is low. While there is a plan for cancer control, this has been hindered by the economic crisis of 1997.

 

Malaysia

There is no nationwide population-based cancer registry in Malaysia, so the burden of cancer is estimated by extrapolating from regional surveys. The likely incidence of cancer is approaching 150 per 100,000 population, with an annual incidence of 30,000 and a prevalence of 90,000. There is an increasing ageing population, so the incidence of cancer is expected to rise. Cancer constitutes 10.3% of medically-certified deaths and is the fourth leading cause of death. The 10 leading cancers among men, women, and children are shown in (Table 7). In 1998, the most common sites for cancer mortality were lung, liver, breast, leukaemia, and stomach.

Malaysia is a multiethnic country, home to people of Chinese, Indian and Malayan origins. Some racial differences have been noted in cancer incidence. For example, the incidence of nasopharyngeal cancer in Chinese is far greater than in Indians or Malays (15.9 per 100,000 population, 1.1 per 100,000 population, and 0.79 per 100,000 population, respectively), and the incidence is greater among men.

Table 7. Ten leading cancer sites in Malaysia.

Men
Women
Children

Lung
Nasopharynx
Stomach
Bladder
Rectum
Non-Hodgkin's
lymphoma
Larynx
Liver
Colon
Oesophagus

Cervix
Breast
Ovary
Lung
Nasopharynx
Oesophagus
Thyroid
Colon
Rectum
Non-Hodgkin's
lymphoma

Leukaemia
Brain and spinal cord
Lymphoma
Neuroblastoma
Gonad and germ cell
Kidney
Soft tissue sarcoma
Retinoblastoma

 

Common cancers for which early diagnosis is possible and effective treatment is available include breast, nasopharyngeal, and oral cavity tumours. However, delay in diag-nosis is common due to frequent reliance on unorthodox medical remedies. Various regional studies have shown that the majority of patients present with advanced disease.

There is a National Cancer Control Programme in Malaysia, which aims to reduce the burden of the disease through prevention, early diagnosis, relief of pain, palliation, and legislative changes such as control of tobacco use. Public education and promotion of healthy lifestyles are to be given more emphasis. With a population that is both knowledgeable and motivated, the incidence of cancer and its associated morbidity and mortality should be reduced.


Pakistan

There is no population-based tumour registry in Pakistan, except in Karachi. However, a local cancer registry has been established in Lahore to determine the pattern of cancer in the Punjab area of Pakistan. Breast cancer was the most common cancer in females while leukaemia and lymphoma were most common among males.

Poor socio-economic status and illiteracy were common and 59% of patients had advanced disease at presentation, which may contribute to the poor cure rates seen in Pakistan. 37% of patients had comorbid hepatitis B or C virus, causing a delay to treatment. Unfortunately, once a diagnosis of cancer was made, not all patients received optimal treatment.

Singapore

According to the Singapore Cancer Registry, which has been in existence for 25 years, approximately 1 in 4 deaths in Singapore are due to cancer, and cancer is the leading cause of death in the state. However, the incidence of cancer is related to the racial distribution of the population. Lung is the commonest cancer in men of all 3 races (Indian, Chinese, and Malay) and breast cancer is the leading site amongst women (Table 8).

Colorectal cancer is the second most common cancer and cervical, stomach, and liver cancers are present in all 3 races. However, Chinese people are more prone to nasopharyngeal and oesophageal cancers, Malays have a slightly higher incidence of lymphoma, and Indians are more prone to laryngeal and oral cancers. Interestingly, these differences are also seen in second-and third-generation immigrants.

Table 8. Ten leading cancer sites in Singapore by race and gender (percentage incidence of all cancers).

Indian
Chinese
Malay
Site
Percent
Site
Percent
Site
Percent
Men
Lung
Prostate Colorectum
Stomach
Liver
Larynx
Bladder
Leukaemia
Mouth
Skin

10.4
9.8
9.5
8.6
7.4
5.1
5.1
4.8
3.6
3.2

Lung
Colorectum
Stomach
Liver
Nasopharynx
Prostate
Skin
Lymphoma
Bladder
Leukaemia

20.1
16.5
9.4
7.9
7.5
5.1
4.3
3.1
2.8
2.7

Lung
Colorectum
Liver
Prostate
Lymphoma
Leukaemia
Nasopharynx
Stomach
Bladder
Skin

19.2
12.9
9.8
7.2
6.8
6.1
4.9
4.2
3.6
3.1

Women
Breast
Colorectum
Ovary
Cervix
Uterus
Stomach
Thyroid
Mouth
Lung
Skin
29.9
9.9
8.7
6.2
5.3
4.2
3.9
3.2
2.9
2.5

Breast
Colorectum
Lung
Cervix
Stomach
Ovary
Skin
Uterus
Thyroid
Nasopharynx

22.0
15.6
9.8
7.3
6.3
5.2
4.5
3.7
2.9
2.8

Breast
Colorectum
Ovary
Cervix
Lung
Uterus
Leukaemia
Thyroid
Lymphoma
Skin

26.8
9.9
8.3
6.7
6.5
5.1
4.0
4.0
3.4
3.4

A national concerted cancer control programme is targeted at prevention, early detection, and integrated management. For example, there is a strong campaign against smoking and a national vaccination programme against hepatitis is in place. Nationwide screening programmes focus on breast and cervical cancer, while awareness clinics for gastric, lung, and colorectal cancers also play a role in the early detection of cancer.

Singapore has several specialised cancer centres, where oncologists work to improve the treatment of cancer. Cancer management and rehabilitation is an important focus of this work. In addition, Singapore has 3 hospices for the care of patients in the terminal stages of the disease.

 

Taiwan

The causes of death have dramatically changed in Taiwan since the economic boom and public health development of the 1950s. Cancer has been the leading cause of death in Taiwan for the past 2 decades. The 5 leading cancers causing mortality are shown in (Table 9). Most cancers have an increasing mortality rate with increasing age. The exceptions are oral and nasopharyngeal cancer for men and breast cancer for females.

 

Table 9. The 5 leading cancers causing mortality in Taiwan for men and women.

Men
Women

Liver
Lung
Stomach
Colon
Oral cavity

Lung
Liver
Cervix
Breast
Stomach

 

There is geographical clustering of some cancers in Taiwan, for example, significantly elevated mortality rates of cancers of the liver, lung, skin, prostate, bladder, and kidney have been observed in the arseniasis-endemic area of Southwest Taiwan. The aboriginal townships of Eastern Taiwan show an elevated mortality rate for oral cancers, due to increased habits of cigarette smoking, alcohol drinking, and betel nut chewing among these women. Aboriginal town-ships also have a high incidence of stomach cancer due to the high prevalence of Helicobacter pylori. Areas of high liver cancer mortality have been noted in the Penghu Islets where residents have a high exposure to aflatoxin.

There are several agencies involved in cancer prevention programmes in Taiwan. The nationwide hepatitis B virus vaccination programme has been successful at preventing liver cancer. Both the chronic hepatitis B virus carrier rate and the incidence of hepatocellular carcinoma have significantly declined since the programme was implemented. There is a tobacco control programme, which has had some success in reducing the prevalence of cigarette smoking among middle-aged men, although young women and adolescents continue to smoke. Finally, there is a move to control the hazards of chewing betel nut.

There is a programme of free mass screening for cervical neoplasia and colorectal cancer and free screening for hepatocellular carcinoma, nasopharyngeal carcinoma, and breast cancer is available for high risk groups. Screening for other cancers is available for a fee. A comprehensive cancer control programme was initiated in 2000. As well as promoting cancer prevention through healthy lifestyles, the programme will implement cancer monitoring and a research system.


Thailand

Cancer is becoming a significant health problem in Thailand with rates comparable to those of other Asian countries. The estimated age-adjusted incidence rates for all sites are 150.4 per 100,000 population for men and 123.0 per 100,000 population for women. There are differences in the incidence of various cancers throughout the country. For example, liver cancer predominates in Khon Kaen in the Northeast, while lung cancer predominates in the North and oesophageal cancer is high in the South. (Table 10) shows the incidences of different cancers in the central area around Bangkok.

Liver cancer is the most common cancer in men and the third most common cancer in women. Hepatocellular is associated with hepatitis B virus, which is a major problem in Thailand, while liver flukes account for the high rates of cholangiocarcinoma in Khon Kaen, which has the highest incidence in the world.

A high incidence of lung cancer has been found among women in Northern Thailand, where the prevalence of smoking is high. However, smoking rates are declining due to strong antismoking campaigns. The incidence of cervical cancer is relatively high in comparison with other developing countries in the area, although there is a low rate of breast cancer. Cancer of the oral cavity is common, with similar rates for men and women. There is an intermediate rate of nasopharyngeal cancer, and low rates of oesophageal and other gastrointestinal cancers.

Several attempts have been made to initiate a cancer control programme, and a review of the National Cancer Control Plan is due. Several activities have been planned, including the control of major cancers in the country through a nationwide campaign. Earlier diagnosis and optimum treatment are 2 important goals for the care of patients with cancer.

Table 10. Incidences of the leading 10 cancers in the central area of Thailand from the Bangkok registry (age-standardised rate per 100,000 population).

Men
Women
Site
Number
Site
Number
Lung
Liver
Colon
Bladder
Oral cavity
Oesophagus
Stomach
Nasopharynx
Rectum
Larynx

21.9
9.7
5.8
5.3
4.4
4.3
4.2
3.6
3.6
3.6

Cervix
Breast
Lung
Colon
Ovary
Oral cavity
Uterus
Liver
Leukaemia
Thyroid

20.9
15.9
6.1
3.5
3.4
3.1
2.8
2.7
2.5
2.3

 

The Philippines

Cancer is the third leading cause of morbidity and mortality in The Philippines, after communicable disease and cardiovascular disease. However, communicable disease mortality is showing a decreasing trend in contrast to increasing trends for cancer and heart disease. 75% of all cancers occur in people older than 50 years, with only 3% occurring in children.

Cancer incidence data come from 2 population-based cancer registries. Between 1980 and 1995, the leading cancer sites have remained unchanged (Table 11). Interestingly, the main cancer sites in The Philippines are those cancers whose primary causes are known, suggesting action may be taken for primary prevention. These sites include lung/larynx (antismoking campaign), liver (hepatitis B virus vaccination), cervix (safe sexual practices), and colon, rectum, and stomach (healthy diet). Except for the high incidence of liver cancer, the pattern in The Philippines is similar to the worldwide pattern of cancer sites.

Most patients seek medical advice only when symptomatic or at an advanced stage of the disease, meaning that the cancer mortality rate is high. For every 2 new cases of cancer diagnosed annually, one patient will die within 1 year. However, there are differences in survival, with lung cancer having the lowest survival rates and breast cancer having the highest. Five-year survival of >40% has only been observed for cancers of the breast, colon, and oral cavity. For all other sites, survival is <30%. These rates suggest that there is much to be done for cancer education and the implementation of cancer prevention strategies.

The Philippines has a cancer control programme, started in 1988. The programme takes an integrated approach, utilising primary, secondary, and tertiary prevention at both hospital and community levels. The main goals of the programme are epidemiology and research, public information and health education, prevention and early detection, treatment, training, and pain relief.

Table 11. Age-standardised incidence rates for the 10 leading cancer sites in the Philippines
(per 100,000 population).

Site
Men
Women

Lung
Breast
Liver
Cervix
Stomach
Colon
Oral cavity
Prostate
Rectum
Leukaemia

64.7
0.8
25.6

12.1
11.8
8.5
19.3
8.1
7.2

18.8
43.2
9.0
26.4
7.6
9.8
8.3

6.2
6.2

 

Vietnam

Due to Vietnam's situation as a developing country, cancer has a low priority, after malnutrition and infectious diseases. However, the pattern of disease in Vietnam is 'transitional' as illnesses related to development such as cancer and cardiovascular disease become more important. There are 2 population-based cancer registries in the country, in Hanoi and Ho Chi Minh City. Cancer of the lung, stomach, liver, colorectum, and nasopharynx are most frequent among men and cancer of the breast, cervix, stomach, colorectum, and lung are most common among females (Table 12).

There are some differences in incidence between the 2 cities, notably that the incidence of cancer of the cervix in the South is almost 4-fold that of the North (Table 12). The estimated incidence of cancer in Vietnam is 133.0 per 100,000 population for men and 91.7 per 100,000 popu-lation for women. The mortality rate is 105.9 per 100,000 population and 58.5 per 100,0000 population for men and women, respectively.

Table 12 . Cancer incidence in Hanoi and Ho Chi Minh City
(age-standardised rate per 100,000 population).

Site
Hanoi
Ho Chi Minh City
Men
Lung
Stomach
Liver
Colorectum
Nasopharynx

38.8
34.5
17
13.3
9.5

24.6
16.5
25.3
9.5
5.1

Women

Breast
Cervix
Stomach
Colorectum
Lung

26.7
6.3
16.4
8
5.6

12.2
26
7.5
8.1
6.8

Vietnam has a high level of tobacco production and consumption. While few women smoke cigarettes, 73.4% of men smoke. There is an active antismoking campaign, although there are a number of obstacles to effective tobacco control in the country. Vaccine against hepatitis B virus is routinely given to newborns to assist in reducing the incidence of liver cancer. Nutrition and nutritional hygiene advice is routinely given to the public by nutritionists and public education about safe sex is widely available.

Most patients present with an advanced stage of the disease due to lack of knowledge and awareness. Downstaging is therefore an important goal of cancer control in Vietnam. There is to be a mass screening programme for cancer of the cervix and instructions for breast self-examination are given regularly on television and in brochures.


Conclusion

The solution to the problem of cancer must involve a multidisciplinary attack. Cancer prevention is likely to be the most cost-effective solution, although comprehensive cancer treatment remains necessary. Cancer care services must be accessible and affordable for all. By achieving this, lives will saved and quality of life improved for patients with cancer.


Further Reading


  1. Alam AM. Existing situation & problems surrounding clinical oncology in Bangladesh. Gan To Kagaku Ryoho 2002;29 (Suppl 1):10-15.
  2. Dong Z, Tang P, Li L, Wang G. The strategy for esophageal cancer control in high-risk areas of China. Jpn J Clin Oncol 2002;32 (Suppl):10-12.
  3. Health Statistics of Hong Kong. Department of Health Annual Report 1998/1999. http://www.info.gov.hk/dh/Annualreport/ Annualreport200002/content02.html
  4. Desai PB. Cancer control efforts in the Indian subcontinent. Jpn J Clin Oncol 2002;32 (Suppl):13-16.
  5. Tjindarbumi D, Mangunkusumo R. Cancer in Indonesia, present and future. Jpn J Clin Oncol 2002;32 (Suppl):17-21.
  6. Ahn YO. Cancer in Korea: present features. Jpn J Clin Oncol 2002;32 (Suppl):32-36.
  7. Lim GC. Overview of cancer in Malaysia. Jpn J Clin Oncol 2002;32 (Suppl):37-42.
  8. Aziz Z, Sana S. Cancer treatment in Pakistan: challenges & obstacles. Gan To Kagaku Ryoho 2002;29 (Suppl 1):4-8.
  9. Hock LC. An overview of the cancer control programme in Singapore. Jpn J Clin Oncol 2002;32 (Suppl):62-65.
  10. Chen CJ, You SL, Lin LH, Hsu WL, Yang YW. Cancer epidemiol-ogy and control in Taiwan: a brief review. Jpn J Clin Oncol 2002;32 (Suppl):66-81.
  11. Vatanasapt V, Sriamporn S, Vatanasapt P. Cancer control in Thailand. Jpn J Clin Oncol 2002;32 (Suppl):82-91.
  12. Ngelangel CA, Wang EH. Cancer and the Philippine Cancer Control Program. Jpn J Clin Oncol 2002;32 (Suppl):52-61.
  13. Anh PT, Duc NB. The situation with cancer control in Vietnam. Jpn J Clin Oncol 2002;32 (Suppl):92-97.

Address for correspondence
Ms Mary Smith
Managing Editor
Oncology Forum
Scientific Communications (UK)
99 Brackenbury Road
London, W6 0BQ
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