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|
Cancer site
|
Annual death rate
|
Stomach |
302,000 |
Hong Kong
Chronic degenerative diseases now constitute the major causes of death in Hong Kong, with the top 3 morbidities of malignant neoplasms, heart disease, and pneumonia representing 32.7%, 15.5%, and 11.3% of all deaths in 1998, respectively. Cancer is the leading cause of death in Hong Kong, being responsible for 1 in every 3 deaths, although the age-standardised rates of death from cancer have gradually declined during the past 20 years. The leading causes of cancer deaths include lung, liver, colon, stomach, nasopharynx, and breast cancers (Table 2). However, this differs between men and women, with women having a lower incidence of lung, liver, and nasopharyngeal cancers than men (Table 2).
Table 2. Main sites of cancer in men and women in Hong Kong.
All sites
|
Men
|
Women
|
Lung |
Lung Liver Colon Nasopharynx Rectum Stomach Bladder Oesophagus Prostate Non-Hodgkin's lymphoma |
Breast |
India
India has a population of approximately 1 billion, of whom 3 million will have cancer at any one time, with an annual incidence of approximately 1 million new patients. While cancer is not a common disease in India, an increasing elderly population ensures that the number of people with cancer will increase in the future.
The cancers most frequently seen in India are lifestyle dependent, associated with tobacco use, low socioeconomic status, multiple pregnancies, early age at marriage, and poor sexual hygiene. For example, males tend to have mainly tobacco-related cancers of the oral cavity, pharynx, larynx, oesophagus, and lung, while females have a high incidence of cervical cancer. These factors tend to be related to the population living in rural surroundings (70% of the population live in rural areas). In addition, low socioeconomic status and low literacy rates ensure that most patients are diagnosed at an advanced stage of the disease making it difficult to achieve cure.
It is difficult to obtain accurate cancer statistics in a large country such as India where only 6 cancer registries function for a population of 1 billion. However, the population- based cancer registry in Mumbai (Bombay) has provided the age-adjusted incidence rates of the 10 leading cancers for men and women (Table 3).
The strategy for cancer control in India should focus on health education for the rural population and the creation of an infrastructure for cancer management. Education is a priority to ensure that the population is aware of prudent lifestyle changes for cancer prevention, symptomatology of early cancer for prompt diagnosis, availability of screening programmes for high-risk populations, and the correlation between early diagnosis and long-term disease-free survival.
While increasing longevity will add to the cancer burden in the future, increasing public awareness and improved technology for early diagnosis will add to the number of people who will be diagnosed with the disease. Although many cancers are preventable through lifestyle changes, the impact of this knowledge in reducing the incidence of cancer will take time. However, cancer mortality rates are steadily declining in countries where appropriate strategies have been implemented.
Table 3. Age-standardised incidence rates* for 10 leading cancer sites in India.
Men
|
Women
|
||
Site
|
Rate per 100,000
|
Site
|
Rate per 100,000
|
Lung Oesophagus Prostate Larynx Stomach Tongue Lymphomas Hypopharynx Liver Leukaemia |
10.7 |
Breast Cervix Ovary Oesophagus Lung Leukaemia Stomach Uterus Lymphoma Colon |
28.1 |
Indonesia
Indonesia is the fifth most populated country in the world after China, India, the Russian Federation, and the USA, with a population of more than 200 million people. While there is an Indonesian cancer society and various research facilities, there are no population-based registries in Indonesia. However, data collected from hospitals in several regions of the country show that the incidence of cancer has increased by up to 8% per year during the past decade.
The 5 main sites for cancer in Indonesia are cervix, breast, lymph node, skin, and nasopharynx. Most patients with cancer are women (65.4%) and the most common female cancer sites are cervix, breast, and ovary (Table 4). An observation period of 4 years (1988 to 1991) shows an increasing rate for each cancer site each year.
Facilities for cancer care have improved in Indonesia. Efforts to control cancer have been undertaken by the government and various other groups. and mainly include prevention, early detection, and treatment. However, rehabilitation, cancer registration, and research are still in their infancy. Activities for primary prevention currently focus on tobacco use, breast self-examination, and screening for cancer of the cervix.
A well-planned cancer control programme aimed at improving cure rates and improved quality of life for patients with cancer is desirable. To achieve these goals, prevention strategies, early detection, diagnosis and treatment, rehabilitation, cancer registration, and research are needed.
Table 4. Ten leading cancer sites in Indonesia according to pathology (1991).
Men
|
Women
|
||
Site
|
Percent
|
Site
|
Percent
|
Skin Nasopharynx Lymph node Unknown primary Rectum Prostate Soft tissue Colon Lung Bladder |
11.59 |
Cervix Breast Ovary Skin Thyroid Unknown primary Lymph node Rectum Nasopharynx Uterus |
28.66 |
Korea
Cancer is one of the most common diseases in Korea, with 50,000 deaths and 80,000 new cases annually. Cancer accounts for 8.3% of all hospital admissions, represented by 9.5% for men and 7.9% for women. According to the Seoul cancer registry data for 1992 to 1995, the crude annual incidence rates for men and women was 184.4 per 100,000 and 158.4 per 100,000, respectively, while the age standardised rate (ASR) for the world population was 290.8 per 100,000 for men and 173.4 per 100,000 for women.
The main cancer site for men and women is the stomach (Table 5). For men, the 4 leading cancer sites of stomach, liver, lung, and colorectum account for two-thirds of all new male cancers. Among women, approximately 60% of all new cancers are accounted for by those of the stomach, cervix, breast, colorectum, and liver. Interestingly, while the leading cancer sites remain relatively similar for men regardless of age, there are differences between older and younger women, notably that middle-aged women (35 to 64 years) are more likely to develop breast cancer than older women, while older women have more lung cancer (Table 6).
Table 5 . Five leading cancer sites in Korea by gender
Men
|
Women
|
||
Site
|
Percent
|
Site
|
Percent
|
Stomach Liver Lung Colorectum Bladder |
24.7 |
Stomach Cervix Breast Colorectum Liver |
17.3 |
Table 6 . Five leading cancer sites in Korea by age.
35-64 years
|
![]() |
||
Site
|
Percent
|
Site
|
Percent
|
Men | |||
Stomach Liver Lung Colorectum Bladder |
26.1 23.2 13.1 8.6 3.0 |
Stomach Lung Liver Colorectum Bladder |
24.1 22.1 11.8 8.8 4.1 |
Women | |||
Cervix Breast Stomach Colorectum Liver |
17.3 |
Stomach Lung Colorectum Liver Cervix |
22.0 |
Of note, is that some parts of Asia, including Korea, have the highest incidence of gastric cancer in the world. A comparison of age incidence curves found that the ASR of gastric cancer for men in Seoul was 10-fold that of men in Los Angeles, USA (71.1 per 100,000 population vs 7.6 per 100,000 population).
Cancer is the leading cause of death in Korea, accounting for 24.1% of all deaths for men and 17.7% for women. There is a marked increase in death rates for people older than 65 years (73% to 75% increase). Gastric cancer mortality has gradually decreased during the past decade, particularly for middle-aged people, while lung cancer mortality is increasing for all age groups. Interestingly, female breast cancer mortality has also increased during the past 10 years.
Early detection or mass screening programmes are available for a fee for specific cancer sites such as stomach, liver, colorectum, breast, and cervix. However, the uptake is less than 10% of the target population and public education is not active. Consequently the early detection rate is low. While there is a plan for cancer control, this has been hindered by the economic crisis of 1997.
Malaysia
There is no nationwide population-based cancer registry in Malaysia, so the burden of cancer is estimated by extrapolating from regional surveys. The likely incidence of cancer is approaching 150 per 100,000 population, with an annual incidence of 30,000 and a prevalence of 90,000. There is an increasing ageing population, so the incidence of cancer is expected to rise. Cancer constitutes 10.3% of medically-certified deaths and is the fourth leading cause of death. The 10 leading cancers among men, women, and children are shown in (Table 7). In 1998, the most common sites for cancer mortality were lung, liver, breast, leukaemia, and stomach.
Malaysia is a multiethnic country, home to people of Chinese, Indian and Malayan origins. Some racial differences have been noted in cancer incidence. For example, the incidence of nasopharyngeal cancer in Chinese is far greater than in Indians or Malays (15.9 per 100,000 population, 1.1 per 100,000 population, and 0.79 per 100,000 population, respectively), and the incidence is greater among men.
Table 7. Ten leading cancer sites in Malaysia.
Men
|
Women
|
Children
|
||
Lung |
Cervix |
Leukaemia Brain and spinal cord Lymphoma Neuroblastoma Gonad and germ cell Kidney Soft tissue sarcoma Retinoblastoma |
Common cancers for which early diagnosis is possible and effective treatment is available include breast, nasopharyngeal, and oral cavity tumours. However, delay in diag-nosis is common due to frequent reliance on unorthodox medical remedies. Various regional studies have shown that the majority of patients present with advanced disease.
There is a National Cancer Control Programme in Malaysia, which aims to reduce the burden of the disease through prevention, early diagnosis, relief of pain, palliation, and legislative changes such as control of tobacco use. Public education and promotion of healthy lifestyles are to be given more emphasis. With a population that is both knowledgeable and motivated, the incidence of cancer and its associated morbidity and mortality should be reduced.
Pakistan
There is no population-based tumour registry in Pakistan, except in Karachi. However, a local cancer registry has been established in Lahore to determine the pattern of cancer in the Punjab area of Pakistan. Breast cancer was the most common cancer in females while leukaemia and lymphoma were most common among males.
Poor socio-economic status and illiteracy were common and 59% of patients had advanced disease at presentation, which may contribute to the poor cure rates seen in Pakistan. 37% of patients had comorbid hepatitis B or C virus, causing a delay to treatment. Unfortunately, once a diagnosis of cancer was made, not all patients received optimal treatment.
Singapore
According to the Singapore Cancer Registry, which has been in existence for 25 years, approximately 1 in 4 deaths in Singapore are due to cancer, and cancer is the leading cause of death in the state. However, the incidence of cancer is related to the racial distribution of the population. Lung is the commonest cancer in men of all 3 races (Indian, Chinese, and Malay) and breast cancer is the leading site amongst women (Table 8).
Colorectal cancer is the second most common cancer and cervical, stomach, and liver cancers are present in all 3 races. However, Chinese people are more prone to nasopharyngeal and oesophageal cancers, Malays have a slightly higher incidence of lymphoma, and Indians are more prone to laryngeal and oral cancers. Interestingly, these differences are also seen in second-and third-generation immigrants.
Table 8. Ten leading cancer sites in Singapore by race and gender (percentage incidence of all cancers).
Indian
|
Chinese
|
Malay
|
|||
Site
|
Percent
|
Site
|
Percent
|
Site
|
Percent
|
Men | |||||
Lung Prostate Colorectum Stomach Liver Larynx Bladder Leukaemia Mouth Skin |
10.4 |
Lung Colorectum Stomach Liver Nasopharynx Prostate Skin Lymphoma Bladder Leukaemia |
20.1 |
Lung Colorectum Liver Prostate Lymphoma Leukaemia Nasopharynx Stomach Bladder Skin |
19.2 |
Women | |||||
Breast Colorectum Ovary Cervix Uterus Stomach Thyroid Mouth Lung Skin |
29.9 9.9 8.7 6.2 5.3 4.2 3.9 3.2 2.9 2.5 |
Breast |
22.0 |
Breast Colorectum Ovary Cervix Lung Uterus Leukaemia Thyroid Lymphoma Skin |
26.8 |
A national concerted cancer control programme is targeted at prevention, early detection, and integrated management. For example, there is a strong campaign against smoking and a national vaccination programme against hepatitis is in place. Nationwide screening programmes focus on breast and cervical cancer, while awareness clinics for gastric, lung, and colorectal cancers also play a role in the early detection of cancer.
Singapore has several specialised cancer centres, where oncologists work to improve the treatment of cancer. Cancer management and rehabilitation is an important focus of this work. In addition, Singapore has 3 hospices for the care of patients in the terminal stages of the disease.
Taiwan
The causes of death have dramatically changed in Taiwan since the economic boom and public health development of the 1950s. Cancer has been the leading cause of death in Taiwan for the past 2 decades. The 5 leading cancers causing mortality are shown in (Table 9). Most cancers have an increasing mortality rate with increasing age. The exceptions are oral and nasopharyngeal cancer for men and breast cancer for females.
Table 9. The 5 leading cancers causing mortality in Taiwan for men and women.
Men
|
Women
|
Liver |
Lung |
There is geographical clustering of some cancers in Taiwan, for example, significantly elevated mortality rates of cancers of the liver, lung, skin, prostate, bladder, and kidney have been observed in the arseniasis-endemic area of Southwest Taiwan. The aboriginal townships of Eastern Taiwan show an elevated mortality rate for oral cancers, due to increased habits of cigarette smoking, alcohol drinking, and betel nut chewing among these women. Aboriginal town-ships also have a high incidence of stomach cancer due to the high prevalence of Helicobacter pylori. Areas of high liver cancer mortality have been noted in the Penghu Islets where residents have a high exposure to aflatoxin.
There are several agencies involved in cancer prevention programmes in Taiwan. The nationwide hepatitis B virus vaccination programme has been successful at preventing liver cancer. Both the chronic hepatitis B virus carrier rate and the incidence of hepatocellular carcinoma have significantly declined since the programme was implemented. There is a tobacco control programme, which has had some success in reducing the prevalence of cigarette smoking among middle-aged men, although young women and adolescents continue to smoke. Finally, there is a move to control the hazards of chewing betel nut.
There is a programme of free mass screening for cervical neoplasia and colorectal cancer and free screening for hepatocellular carcinoma, nasopharyngeal carcinoma, and breast cancer is available for high risk groups. Screening for other cancers is available for a fee. A comprehensive cancer control programme was initiated in 2000. As well as promoting cancer prevention through healthy lifestyles, the programme will implement cancer monitoring and a research system.
Thailand
Cancer is becoming a significant health problem in Thailand with rates comparable to those of other Asian countries. The estimated age-adjusted incidence rates for all sites are 150.4 per 100,000 population for men and 123.0 per 100,000 population for women. There are differences in the incidence of various cancers throughout the country. For example, liver cancer predominates in Khon Kaen in the Northeast, while lung cancer predominates in the North and oesophageal cancer is high in the South. (Table 10) shows the incidences of different cancers in the central area around Bangkok.
Liver cancer is the most common cancer in men and the third most common cancer in women. Hepatocellular is associated with hepatitis B virus, which is a major problem in Thailand, while liver flukes account for the high rates of cholangiocarcinoma in Khon Kaen, which has the highest incidence in the world.
A high incidence of lung cancer has been found among women in Northern Thailand, where the prevalence of smoking is high. However, smoking rates are declining due to strong antismoking campaigns. The incidence of cervical cancer is relatively high in comparison with other developing countries in the area, although there is a low rate of breast cancer. Cancer of the oral cavity is common, with similar rates for men and women. There is an intermediate rate of nasopharyngeal cancer, and low rates of oesophageal and other gastrointestinal cancers.
Several attempts have been made to initiate a cancer control programme, and a review of the National Cancer Control Plan is due. Several activities have been planned, including the control of major cancers in the country through a nationwide campaign. Earlier diagnosis and optimum treatment are 2 important goals for the care of patients with cancer.
Table 10. Incidences of the leading 10 cancers in the central area of Thailand from the Bangkok registry (age-standardised rate per 100,000 population).
Men
|
Women
|
||
Site
|
Number
|
Site
|
Number
|
Lung Liver Colon Bladder Oral cavity Oesophagus Stomach Nasopharynx Rectum Larynx |
21.9 |
Cervix Breast Lung Colon Ovary Oral cavity Uterus Liver Leukaemia Thyroid |
20.9 |
The Philippines
Cancer is the third leading cause of morbidity and mortality in The Philippines, after communicable disease and cardiovascular disease. However, communicable disease mortality is showing a decreasing trend in contrast to increasing trends for cancer and heart disease. 75% of all cancers occur in people older than 50 years, with only 3% occurring in children.
Cancer incidence data come from 2 population-based cancer registries. Between 1980 and 1995, the leading cancer sites have remained unchanged (Table 11). Interestingly, the main cancer sites in The Philippines are those cancers whose primary causes are known, suggesting action may be taken for primary prevention. These sites include lung/larynx (antismoking campaign), liver (hepatitis B virus vaccination), cervix (safe sexual practices), and colon, rectum, and stomach (healthy diet). Except for the high incidence of liver cancer, the pattern in The Philippines is similar to the worldwide pattern of cancer sites.
Most patients seek medical advice only when symptomatic or at an advanced stage of the disease, meaning that the cancer mortality rate is high. For every 2 new cases of cancer diagnosed annually, one patient will die within 1 year. However, there are differences in survival, with lung cancer having the lowest survival rates and breast cancer having the highest. Five-year survival of >40% has only been observed for cancers of the breast, colon, and oral cavity. For all other sites, survival is <30%. These rates suggest that there is much to be done for cancer education and the implementation of cancer prevention strategies.
The Philippines has a cancer control programme, started in 1988. The programme takes an integrated approach, utilising primary, secondary, and tertiary prevention at both hospital and community levels. The main goals of the programme are epidemiology and research, public information and health education, prevention and early detection, treatment, training, and pain relief.
Table 11. Age-standardised incidence rates for the 10 leading cancer sites in the Philippines
(per 100,000 population).
Site
|
Men
|
Women
|
||
Lung |
64.7 |
18.8 |
Vietnam
Due to Vietnam's situation as a developing country, cancer has a low priority, after malnutrition and infectious diseases. However, the pattern of disease in Vietnam is 'transitional' as illnesses related to development such as cancer and cardiovascular disease become more important. There are 2 population-based cancer registries in the country, in Hanoi and Ho Chi Minh City. Cancer of the lung, stomach, liver, colorectum, and nasopharynx are most frequent among men and cancer of the breast, cervix, stomach, colorectum, and lung are most common among females (Table 12).
There are some differences in incidence between the 2 cities, notably that the incidence of cancer of the cervix in the South is almost 4-fold that of the North (Table 12). The estimated incidence of cancer in Vietnam is 133.0 per 100,000 population for men and 91.7 per 100,000 popu-lation for women. The mortality rate is 105.9 per 100,000 population and 58.5 per 100,0000 population for men and women, respectively.
Table 12 . Cancer incidence in Hanoi and Ho Chi Minh City
(age-standardised rate per 100,000 population).
Site
|
Hanoi
|
Ho Chi Minh City
|
||
Men | ||||
Lung Stomach Liver Colorectum Nasopharynx |
38.8 |
24.6 |
||
Women | ||||
Breast |
26.7 |
12.2 |
Vietnam has a high level of tobacco production and consumption. While few women smoke cigarettes, 73.4% of men smoke. There is an active antismoking campaign, although there are a number of obstacles to effective tobacco control in the country. Vaccine against hepatitis B virus is routinely given to newborns to assist in reducing the incidence of liver cancer. Nutrition and nutritional hygiene advice is routinely given to the public by nutritionists and public education about safe sex is widely available.
Most patients present with an advanced stage of the disease due to lack of knowledge and awareness. Downstaging is therefore an important goal of cancer control in Vietnam. There is to be a mass screening programme for cancer of the cervix and instructions for breast self-examination are given regularly on television and in brochures.
Conclusion
The solution to the problem of cancer must involve a multidisciplinary attack. Cancer prevention is likely to be the most cost-effective solution, although comprehensive cancer treatment remains necessary. Cancer care services must be accessible and affordable for all. By achieving this, lives will saved and quality of life improved for patients with cancer.
Further Reading
Address for correspondence |